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Experimental studies have demonstrated that supplementation with cysteine precursors, such as NAC, or GlyNAC (a combination of glycine and NAC), can restore intracellular GSH pools, mitigate oxidative stress, and improve mitochondrial function, thereby potentially counteracting several hallmarks of aging [20,21,199,200]
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A variety of drugs have directly targeted the NMDA-R glycine binding site as co-agonists (Glycine, D-serine, D-cycloserine, or D-alanine)