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Aetiologies of primarily neuropathic pain include peripheral pathologies such as chronic alcohol consumption, cancer, drug toxicity, diabetes mellitus, herpes zoster infection, traumatic nerve injuries, as well as central processes including cerebrovascular accidents, multiple sclerosis and spinal cord injuries [2,3,4,5,6,7]

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In the case of hM4D(Gi), the mouse’s head was sutured, and one month was allowed for recovery and expression