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At the time, the authors observed that, while lymphocyte atypia decreased in the blood count, the eosinophilia progressively increased, configuring a characteristic hematological evolution of what is currently called DRESS syndrome.8 In 1949, Lowe and Smith were the first to publish what would be called dapsone hypersensitivity syndrome or sulfone syndrome, when they observed a 2% incidence of development of exfoliative dermatitis in patients receiving dapsone to treat leprosy.9 In 1951, sulfone syndrome was described as a mononucleosis-like syndrome characterized by the occurrence of exfoliative dermatitis, hepatomegaly, jaundice, splenomegaly, lymphadenopathy and a predominance of mononuclear cells in the peripheral blood, in patients treated for less than two months with the drug