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Membrane lipids that exist in the crystalline phase in normal conditions may become solidify at non-physiological temperatures thus their functions become altered that eventually initiates various processes that increase damage to membrane lipids such as distraction of lipid and proteins connections and various proteins including ion passages may translocated or lost their function [31], as well as the formation of ROS or destabilize the cellular membrane thereby loos its selective permeability which enhances the influx of ions, for example, Ca2+ and bicarbonates from extracellular space [32]