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As permeant ion channel blockers of AMPARs and KARs, cytoplasmic polyamines (spermine, spermidine, putrescine) have been identified as critical modulators of neuronal signaling, influencing action potential firing rates as well as the efficacy of neurotransmission (Nichols and Lopatin, 1997)

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Further articles have dealt with the role of one chosen vitamin, its deficiency or excess in the pathogenesis of asthma, and the possibility of its supplementation in the treatment of the disease