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David Perlmutter, MD, FACN, ABIHM

GSH depletion does not regulate GPX4 protein levels or ferroptosis sensitivity to class 2 FINs The aforementioned data prompted us to study how SLC7A11-mediated cystine transport promotes GPX4 protein synthesis

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In fact, decreased insulin levels in animal models of DM have been shown not only to decrease transporter translocation, but also to attenuate expression of Glut4 in muscle cells