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Critical Role of Mitochondrial Fatty Acid Metabolism in Normal Cell Function and Pathological Conditions - PMC

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While mTOR inhibitors (e.g., sirolimus) and AMPK activators (e.g., metformin) have shown promise in clinical trials for SLE and RA, their effects are often accompanied by off-target consequences, such as hyperlipidemia and infection risk, highlighting the need for more selective targeting

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