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Importantly, in the hypothalamus, GLP-1 receptor activation stimulates the neuronal pathways that reduce appetite and food intake

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Hypoxia also promotes the production of various such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B (NF-κB), leading to tissue inflammation response (Pu et al., 2022)