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The one real argument for injecting is bypassing first-pass metabolism, and the strength of that argument depends entirely on which bioavailability study you believe (3.5% in mice versus 38.4% in rats)

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[DOI] [PubMed] [Google Scholar] 40.de Vogel S., Meyer K., Fredriksen A., Ulvik A., Ueland P.M., Nygard O., Vollset S.E., Tell G.S., Tretli S., Bjorge T