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DCs treated with Sm29 exhibited several characteristics of a tolerogenic profile: higher expression of HLA-DR, CD83, CD80, and CD86 as well as of IL-10 and IL-10R, and increased the frequency of CD4+ T-cells expressing the regulatory molecules CTLA4 and CD25 (47)

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These findings highlight the promise of AITC-mediated EXOs miR16 enrichment as an efficient strategy to suppress cancer growth and progression, as well as a novel possibility for the treatment of cancer (Ganesh et al., 2025)