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Hypoxia induces the activation and stabilization of HIF-1 transcription factor (section 3.1), which subsequently governs the gene expression linked to various processes, including metabolism, angiogenesis, and stress response

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The conclusion was drawn that despite exposure to relatively low concentration levels of inspirable flour dust, subjects working in the baking industry are at risk of developing both respiratory symptoms and airway hyperresponsiveness (Bohadana et al., 1994)