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Reconstitution and administration for both peptides Both cagrilintide and retatrutide are typically supplied as lyophilized (freeze-dried) powders that require reconstitution with bacteriostatic water before use

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While cagrilintide rapidly modulated gene expression in AP Calcr/Ramp3 neurons in obese mice and rats, long-term cagrilintide treatment activated NTS Calcr/Prlh neurons and upregulated Prlh expression specifically in rats, suggesting a role for these cells in the long-term response to cagrilintide

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