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FIGURE 3 In summary, this evidence suggests that the origin of excess ROS production is the result of (1) defective mitochondria (due to the abnormal and reduced distribution of cardiolipins) with high intermembrane electrical potential and (2) reduced mitophagy process (due to high expression and activity of P53 protein)

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[2] Moderate Dose (1.5-3.0 mg/kg) This therapeutic range, equivalent to 105-210 mg daily in humans, produces the side effect profile described in the common effects section