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As per Rahimi’s (83) findings, it has been observed that the endothelium possesses tightly specialized cell-to-cell junctions, which function as a selective barrier to impede the passage of macromolecules

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Previous reports indicated that oral vitamin B12 successfully treats patients with pernicious anemia who have defects in the main vitamin B12 absorption mechanisms as a result of the presence of autoantibodies specific for intrinsic factor or a history of surgical resection of the ileum [9–11]