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The high surface reactivity, engineered to break down robust chemical bonds in a pollutant, can similarly disrupt the delicate lipoprotein structures of a cell membrane.22,23 The capacity of a semiconductor nanoparticle like TiO2 to generate highly oxidising hydroxyl radicals (˙OH) for mineralising a dye molecule is the same process that induces oxidative stress, lipid peroxidation, and genotoxicity in aquatic organisms.22 The strong affinity of a surface-functionalised ENM for capturing a heavy metal ion is governed by the same chemical principles that might allow it to strip essential metallic co-factors from vital enzymes