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Mitochondrial DNA oxidation, lactate-induced modification of NLRP3, and the interaction of NLRP3 with the adaptor protein NEK7 further contribute to inflammasome activation by promoting NLRP3 conformational changes and oligomerization (69–71)

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Originally studied for its role in gut health, particularly within the gastrointestinal tract, it has since been recognized for supporting tissue resilience and helping maintain the body’s natural processes