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The systematic analysis found that cartilage lesions complicated by limited progenitor cell activity and healing capacity, large size, high mechanical demands, local and systemic inflammation, or other systemic diseases are often excluded from treatment, likely due to complications and poor outcomes after cartilage restoration procedures in this context

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However, in diabetic patients, wound healing is often disrupted by multiple factors, causing dysregulation in hemostasis, inflammation, proliferation, and remodeling phases, which ultimately lead to chronic wounds