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Acute use of either desipramine or fluoxetine did not alter IP3 or PLC activity in membrane or cytosol, but 21-day chronic use of either antidepressant produced a significant decrease in IP3-PLC activity in both membrane and cytosol, specific to PLC-1beta, suggesting that chronic antidepressant use depressed the PKC pathway (Dwivedi et al., 2002)

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