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Both molecules (0.1–10 μM) stimulated the proliferation of keratinocytes in a dose dependent manner and resulted in changes in epidermal basal cells whose integrins and p63 expression markedly increased

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However, self-injection presents its own challenges for patients – they are frequently non-expert users and must be responsible for proper and safe storage, complex preparation (sometimes including mixing and reconstitution), accurate dosing and the safe disposal of potentially dangerous sharps waste