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Ozempic is FDA-approved for two indications: To improve blood sugar control in adults with type 2 diabetes To reduce the risk of major cardiovascular events, such as heart attack or stroke, in adults with type 2 diabetes and heart disease Wegovy is also FDA-approved for two indications: To reduce body weight and maintain weight loss in adults and children ages 12 and up with obesity, as well as in adults with overweight and at least one weight-related health condition To reduce the risk of major cardiovascular events, such as heart attack or stroke, in adults with heart disease and either obesity or overweight Rybelsus is FDA-approved to treat type 2 diabetes by improving blood sugar control

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Increased folate serum levels may be associated with a higher risk of lung cancer [124], breast cancer [125], and even CRC [126], where low levels are also associated with increased CRC risk