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Specific statistical tests and sample sizes ( n ) are detailed in the figures and/or figure legends, where n refers to the number of animals or samples for in vivo and in vitro experiments, respectively

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Target proteins quantified through parallel reaction monitoring (PRM) For further confirming the proteomics data, fifty DEPs were selected and measured through PRM-MS analysis at Jingjie PTM BioLab (Hangzhou), Co, Ltd, Hangzhou, China