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These effects were mediated through the beta-3 adrenergic receptor pathway and were absent in beta-3 AR knockout animals

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In contrast, MCL1 mRNA levels anti-correlated with AR-A in 3 (i.e., Rajan, Sharma, and Long) of the 4 nADT datasets and BCL2A1 (encoding A1/BFL1) showed an inverse correlation with AR-A only in the Long cohort (supplementary Fig