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Supporting information ACKNOWLEDGMENTS This work was supported by funding from the Science and Technology Development Fund, Macau SAR (file 0077/2020/A2, 0099/2022/AFJ, 0061/2022/A) and from the University of Macau (file: MYRG2022‐00251‐FHS)

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however, the mechanisms of action and primary focuses of BBR and metformin are not identical