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34 Identifying specific ligands for E3 ligases can be challenging due to the lack of known ligands for many of these proteins

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Chronic alcoholism causes a reduction in the con­ver­sion of tryp­to­phan to niacin, arising from inhibition of tryp­to­phan 2,3-dioxygenase, a rate-limiting enzyme of the hepatic kynurenine path­way of tryp­to­phan degrad­ation and niacin synthesis (Prabhu et al., 2021)