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We also introduced R242E, K244E, and R249E point mutation or R242E/K244E/R249E triple mutation to the K2 domain of HGF, and showed that all the HGF-K2 mutants exhibited lower potency in activating c-MET as compared with wild-type HGF (Fig

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Research on inhibitory activity of small molecular compounds on tumor growth & metastasis via inhibiting angiogenesis and mechanism