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Glutathione Disulfide - an overview | ScienceDirect Topics

Phytochemicals are bioactive compounds found in plants, known for their diverse pharmacological effects, including anti-inflammatory, antioxidant, and antispasmodic activities

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The review also details the effect of the oxetane motif on important properties, including aqueous solubility, lipophilicity, pKa, P-glycoprotein (P-gp) efflux, metabolic stability, conformational preferences, toxicity profiles (e.g., cytochrome P450 (CYP) suppression and human ether-a-go-go related gene (hERG) inhibition), pharmacokinetic (PK) properties, potency, and target selectivity