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Decreased GSH levels have been shown to activate NFκB, leading to a series of downstream signal transduction events that allow HIV expression [77]

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It inhibits the NLRP3 inflammasome in renal macrophages by enhancing AMPK-mediated autophagy, thereby reducing caspase-1 activation and the secretion of IL-1β/IL-18, which are key mediators of tubulointerstitial injury (107)