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Timing of Parenteral Nutrition in Neonates, Infants, and Children: Current Evidence, Circadian Considerations, and Emerging Directions

4.1.1 Core cell types and their roles As the main inflammatory cells infiltrating the airways, neutrophils disrupt the integrity of the airway epithelium by releasing elastase and matrix metalloproteinases (MMP-9), while secreting IL-8 and TNF-α to amplify the inflammatory cascade (24, 25)

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These factors lead to an easier buildup of free radicals and accumulation of toxins, which the body copes with with its natural first line of defense of antioxidants, which often may not be sufficient