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Music can impact the brain stem, stimulate the cerebral cortex, regulate peripheral nerves, strengthen muscles, and boost physical vitality in stroke patients ( 7 Clinical trials of ischemia stroke A randomized clinical trial showed that patients with acute ischemic stroke who received Tongxinluo along with their usual medication within 72 h of symptom onset had a better functional outcome compared to those who received a placebo (Zhang et al., 2015)