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A phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of pf-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis
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184,187,196,197 PCR generates linear dsDNA containing only a single copy of the template and requires thermal cycling, whereas RCA leverages a circular template, exonuclease resistant primers, and a strand displacing polymerase to generate large fragments of mixed ssDNA and dsDNA containing many copies of the template in a single molecule