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Bioinformatics analysis of RNA sequencing data from 31 types of cancers in TCGA revealed that high GPX1 expression levels indicate worse OS and disease-free survival (DFS) prognosis in LGG and AML but better OS in KIRP [68]

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In contrast, changes in the levels for GSH-catabolic enzymes (GPX1/2/3, GGT and GSTpi/m1/zi) varied greatly between cell line pairs and enzyme subtypes indicating no clear pattern (Figure 2b)