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Mitochondrial dysfunction in Parkinson's disease – a key disease hallmark with therapeutic potential | Molecular Neurodegeneration | Springer Nature Link

(34) reported significantly increased PBR28 signal in many brain structures following LPS-injection, including bilateral caudate nucleus and putamen of the basal ganglia, large areas of the neocortex, amygdala, hippocampus, and thalamus

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This is why people with stomach surgery, autoimmune gastritis, or long-term PPI use can develop B12 deficiency despite adequate dietary intake