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Five to 7 month old cats had no side effects with daily treatments of 15 mg/kg for 30 days, but 2 of 4 animals had articular cartilage lesions when administered 25 mg/kg per day for 30 days

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Therefore, randomized (placebo)‐controlled trials could not provide robust evidence for long‐term safety and efficacy on pain relief in CD‐LBP of any of these therapeutic agents