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Mechanistically, GSTM3 knockdown in TMZ-resistant cells did not alter LDHA mRNA abundance, yet it significantly reduced LDH enzymatic activity and L-lactate production, accompanied by suppressed glycolytic capacity and increased TMZ cytotoxicity [38]
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Several drug candidates are presently in diverse phases of clinical development (Figure 2), comprising reoptimized adaptations of current TB drugs and some involving original mechanisms of action