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Similar content being viewed by others Introduction Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, whose clinical course is mostly driven by the selective degeneration of both upper and lower motor neurons (MNs), at the level of motor cortex, brainstem and spinal cord
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Redox homeostasis is controlled by a variety of cell defense mechanisms, including three different superoxide dismutase (SOD1 in cells, SOD2 in mitochondria, SOD3), glutathione peroxidase (GPX), and signal pathways Nuclear factor erythroid 2-related factor 2 (NRF2)- Kelch-like ECH-associated protein 1(KEAP1) (71)