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The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors - PMC

Results Chronic iron accumulation and GSH depletion remodel labile iron pools and induce ferritin expression Our experimental design employed two complementary stress paradigms: (1) chronic iron accumulation to model age-related brain iron overload and (2) chronic GSH depletion using buthionine sulfoximine (BSO) to investigate the role of GSH loss independent of exogenous iron, since preliminary observations suggested a mechanistic link between iron and GSH dysregulation

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While Dihexa shows promising benefits, it’s still a powerful compound that should be used wisely—with the right expectations, precautions, and support