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For example, LncRNA1764 has been shown to enhance the translation of the c-Myc protein, thereby promoting CRC cell survival, metastasis, and resistance to chemotherapeutic agents such as 5-fluorouracil by augmenting metabolic flux (219)

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Using a novel approach to target RNA splicing, scientists have also demonstrated the therapeutic benefits of ASOs to modulate protein levels of synaptic Ras GTPase-activating protein 1 (SynGAP1) (Jeyabalan and Clement, 2016)