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Due to these properties, from 1970 to 2004, β-carotene was used for cutaneous porphyria, especially on EPP patients [69,70,71]
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Research Background 🧪 In Vitro Studies Models: Keratinocytes, fibroblasts, endothelial cells Methods: Gene-expression profiling, microscopy, collagen quantification Findings: Up-regulation of more than 400 genes related to wound healing and tissue remodeling Enhanced collagen and growth-factor synthesis Accelerated closure of cellular wounds under stress conditions 🧍♂️ In Vivo Animal Research Models: Burns, skin wounds, alopecia, and age-related tissue decline Results: Wound healing accelerated by 30–50 % compared to control Restoration of collagen fiber networks and capillary density Noticeable dermal thickening and improved hair density Enhanced elasticity and reduced wrinkle depth in topical models 👩⚕️ Human Clinical Observations Volunteer studies show GHK-Cu is safe, non-irritating, and effective in improving skin texture and tone
