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For cells whose glucose uptake is not dependent on insulin, glucose oversupply can lead to NADH overproduction by both the conventional glucose combustion pathways (glycolysis and Krebs cycle) and the polyol pathway

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therefore, downregulation of GLUT-1 directly compromises energy supply to neural cells, exacerbating metabolic stress and cell death in both neurons and glial cells, thereby contributing to a vicious cycle of injury (158)