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Folate deficiency during this period is associated with the development of autism spectrum disorders in children, neural tube irregularity, and brain development defects in the fetus and brain function in later life (, , , , )

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In an eight-week, randomized, placebo-controlled trial that included 46 menopausal women being treated with citalopram (Celexa), the addition of vitex (equivalent of 1,000 mg dried vitex berry daily) plus black cumin ( Nigella sativa , 500 mg ground seeds daily) to treatment resulted in greater improvements in hot flashes and physical and psychosocial functioning compared with placebo