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84 Epigenetic alterations such as histone modifications (e.g., H3K9me3 loss) contribute to the upregulation of inflammatory genes and an imbalance in macrophage polarization, further reinforcing systemic inflammation

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[ 323 ] Instead, deletion of Progesterone receptor membrane component 2 (PGMRC2) in brown fat, an intracellular haem chaperone, decreases labile haem in the nucleus and improves the stability of BACH1, which is the haem‐responsive transcriptional suppressor, resulting in higher fasting glycemia, reduced glucose tolerance and insulin sensitivity, hyperlipidemia, and exacerbated liver steatosis in mice with HFD