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This is driven by B cells polyclonal activation, resulting in the production of large amounts of low-affinity anti- Leishmania antibodies and the formation of multiple immune complexes (161)

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These findings suggest that, beyond their role in regulating the biosynthesis of CD4 + T cell building blocks and supporting cell proliferation, the oxysterol receptor LXRs also play a pivotal role in modulating the differentiation of Teff cell subsets (Fig