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Operating on a patient with an uncorrected B12 deficiency increases the risk of: Impaired wound healing and a higher chance of wound breakdown Post-operative fatigue and slower recovery, particularly if anaemia is also present Elevated homocysteine, which feeds into an already elevated DVT risk profile A sub-optimal immune response during the early wound healing phase None of these is certain to happen

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117–120 Emerging techniques such as genetic code expansion further enable the introduction of non-canonical amino acids, significantly expanding the structural and functional diversity of peptide therapeutics