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For instance, the multi-kinase inhibitor sorafenib, which also functions as system Xc - inhibitor [138] , is being investigated and is in a phase Ib/II trial in combination with pembrolizumab (anti-PD-1) for advanced hepatocellular carcinoma (NCT03211416) [22,139] , leveraging the ability of ferroptotic cells to enhance the immunogenicity of the TME