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Evidence from animal models suggest that improvements in spatial memory following an acute bout of resistance exercise may be mediated via IGF-1, however the relationship between IGF-1 and short term cognitive performance in humans remains unclear (Vega et al., 2010) elicits an increase in circulating serum IGF-1 in young adults, similar to both moderate (50% 1RM) and high-intensity (80% 1RM) resistance exercise (Tsai et al., 2014)