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reported that butyrate can reduce hippocampal neuronal apoptosis in epilepsy, exerting direct neuroprotective effects (44)

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It also helps in reversing the imbalance of matrix metalloproteinases (MMP-9) and their inhibitors (TIMP-1), and in preventing epithelial-mesenchymal transition (EMT) through the modulation of Nrf2, NF-κB, and TGF-β1/Smad2/3 signaling pathways 6