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The receptor antagonist IL-1Ra is produced by some cells of the joint and can link with IL-1R1 and IL-1R2

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conducted a study that revealed how CHD8 haploinsufficiency disrupts the development of the nervous system, leading to an imbalance between the generation of inhibitory and excitatory neurons and resulting in an abnormal enlargement of cerebral organoids consistent with the macrocephaly demonstrated in patients [126]