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In combinazione con la fototerapia a LED (625-635 nm), il GHK-Cu ha mostrato un incremento della vitalità cellulare di 12,5 volte e della produzione di collagene del 70% rispetto alla sola irradiazione , suggerendo un ruolo importante nei trattamenti professionali combinati

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Indeed, accumulation of ROS can lead to an activation of the DDR response and subsequent activation of p53 105, but could also lead to a specific activation of FOXO4 via the ROS/JNK and/or ROS/MDM2 pathways as discussed previously 73, 74, 75, 95 and possibly contributes to the observed senescence‐like phenotype