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Numerous studies have revealed the critical role of pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), expressed by both DCs and epithelial cells, in the recognition of a wide range of environmental pathogens, which initiates an adaptive immune response ( Figure 1 ( Figure 2A ( Figures 2B–E ( Epidemiological studies indicate that asthma affects about 300 million people worldwide and is more prevalent in boys and women ( The Global Initiative for Asthma (GINA) has identified three distinct “endotypes” of asthma: early-onset atopic asthma responsive to steroids, late-onset eosinophilic asthma associated with steroid resistance, and asthma responsive to leukotriene modifiers, each with distinct molecular mechanisms and treatment responses based on pathophysiological mechanisms ( Multi-layered visual map of biomolecular interactions in the airway microenvironment