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The average maximum temperature throughout the growth period was 11.5 °C

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Of note, among the most characterized targets of NRF2, haem oxygenase 1 (HMOX1) has been found to be synthetic lethal with FH 8 suggesting that the activation of NRF2 and its downstream targets might have an important prosurvival role in Fh1-deficient cancer cells, beyond the control of redox homeostasis